CD56 Monoclonal Antibody

Catalogue Numbers: MB65795-50, MB65795-100

Sizes: 50µl, 100µl

Product: Mouse IgG2a kappa. Liquid in PBS, pH 7.3, 0.2% BSA, and 0.02% sodium azide.

Swiss-Prot: P13591

Host: Mouse

Reactivity: Human

Applications: IF, FC

All Applications: IF (1/50 - 1/200)

Background: NCAM (neural cell adhesion molecule, CD56) is an adhesion glycoprotein with five extracellular immunoglobulin-like domains followed by two fibronectin type III repeats. Structural diversity is introduced by alternative splicing resulting in different cytoplasmic domains. NCAM mediates neuronal attachment, neurite extension, and cell-cell interactions through homo and heterophilic interactions. PSA (polysialic acid) post-translationally modifies NCAM and increases the metastatic potential of small cell lung carcinoma, Wilms+ tumor, neuroblastoma, and rhabdomyosarcoma. CD56 is commonly used along with CD3 and CD16 to identify human NK cells (Mouse NK cells do not express CD56). Human natural killer cells are CD3-CD56+. The large subset with high CD16 expression are mature cytotoxic natural killer cells, while those with low CD16 expression are immature precursors and cytokine producers.

Purification and Purity: The monoclonal antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes human CD56

Extra Notes: Flow cytometric analysis of human peripheral blood lymphocytes using Anti-CD56 Antibody, followed by anti-mouse IgG PE.

Bioworld Molecular Weight: ~ 94 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: NCAM; Neural cell adhesion molecule 1; N-CAM-1; NCAM-1; CD antigen CD56

Immunogen: Native purified human CD56.

Conjugate: Unconjugated

Modification: Unmodified