AM12 inhibits Lanthanide-evoked TRPC5 activity with an IC50 of 0.28 μM.

Product information

CAS Number: 2387510-84-9

Molecular Weight: 349.13

Formula: C15H9BrO5

Chemical Name: 2-(2-bromophenyl)-3,5,7-trihydroxy-4H-chromen-4-one

Smiles: OC1C(=O)C2=C(C=C(O)C=C2O)OC=1C1=CC=CC=C1Br

InChiKey: OVIAJBSVWWYJSD-UHFFFAOYSA-N

InChi: InChI=1S/C15H9BrO5/c16-9-4-2-1-3-8(9)15-14(20)13(19)12-10(18)5-7(17)6-11(12)21-15/h1-6,17-18,20H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

AM12 also inhibits TRPC5 activity evoked by the agonist (-)-Englerin A. AM12 also inhibits TRPC4 channels similarly. AM12 inhibits TRPC5 and TRPC4 channels via a site accessible from the extracellular face of the membrane, acting directly on either the channel or a site closely associated with it. AM12 also inhibits Ca2+ entry evoked by Gd3+. AM12 inhibits the Gd3+-evoked Ca2+ signal with an IC50 of 0.28 μM. AM12 is slightly more potent than the natural product Galangin as an inhibitor of the Gd3+-evoked signal.

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