SK1-IN-1 is a potent sphingosine kinase 1 (SPHK1) inhibitor with an IC50 of 58 nM.

Product information

CAS Number: 1218816-71-7

Molecular Weight: 398.50

Formula: C22H30N4O3

Chemical Name: (2S,3S)-N-[(1S)-1-{4-[5-(2-cyclopentylethyl)-1,2,4-oxadiazol-3-yl]phenyl}ethyl]-3-hydroxypyrrolidine-2-carboxamide

Smiles: C[C@H](NC(=O)[C@H]1NCC[C@@H]1O)C1=CC=C(C=C1)C1N=C(CCC2CCCC2)ON=1

InChiKey: GDJANRNMFHNVOW-DCPHZVHLSA-N

InChi: InChI=1S/C22H30N4O3/c1-14(24-22(28)20-18(27)12-13-23-20)16-7-9-17(10-8-16)21-25-19(29-26-21)11-6-15-4-2-3-5-15/h7-10,14-15,18,20,23,27H,2-6,11-13H2,1H3,(H,24,28)/t14-,18-,20-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 100 mg/mL (250.94 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

SK1-IN-1 demonstrates significant improvement in the intrinsic clearance, particularly against human liver microsomes. SK1-IN-1 is selected for rat PK studies and demonstrates modest in oral bioavailability with acceptable half-lives in blood circulation.

Products are for research use only. Not for human use.