SWAP-70 Monoclonal Antibody

Catalogue Numbers: MB67240-50, MB67240-100

Sizes: 50µl, 100µl

Product: Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: Q9UH65

Host: Mouse

Reactivity: Human

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: SWAP70 is a Rac family guanine nucleotide exchange factor (GEF). It is highly expressed by activated B cells. Following B cell stimulation, SWAP70 has been observed to translocate from the cytoplasm to the nucleus, where it plays a role in class switching, as well as to the membrane, where it associates with the B cell receptor. SWAP70 also plays a role in migration of B cells and other immune cell types including dendritic cells, eosinophils, and mast cells. Mice deficient in both SWAP70 and a related protein, DEF6, develop lupus-like autoimmunity due to misregulation of IRF4 in B cells and T cells leading to increased IL21 production and responsiveness.

Purification and Purity: This antibody is purified through a protein G column.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of SWAP-70 protein.

Extra Notes: Western blot analysis of SWAP-70 expression in HL60 (A) whole cell lysates.

Bioworld Molecular Weight: ~ 70 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: KIAA0640; Switch-associated protein 70; SWAP-70

Immunogen: Recombinant fusion protein of human SWAP-70. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified