IFN-ω Polyclonal Antibody

Catalogue Numbers: BS60296-50, BS60296-100

Sizes: 50µl, 100µl

Alternative Name: Interferon omega-1; Interferon alpha-II-1; IFNW1

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P05000

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: The genes encoding type I interferons (IFNs), which include 14 IFN-α genes, 1 IFN-β gene, 1 IFN-ω (also known as IFN-α II1) gene, and a number of IFN-ω pseudogenes, are clustered on human chromosome 9. Interferons-α and -β are cytokines that are widely known to induce potent anti-viral activity. IFN-α and -β exert a variety of other biological effects, including anti-tumor and immunomodulatory activities and are increasingly used clinically to treat a range of malignancies, myelodysplasias and autoimmune diseases. IFN-ω is antigenically different from human IFN-α, IFN-β or IFN-γ, but is a component of natural mixtures of IFN species produced by virus-induced leukocytes or Burkitt's lymphoma cells. The Type I interferon receptor (IFN-αR) interacts with IFN-α, IFN-β and IFN-ω, and seems to be a multisubunit receptor.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IFN-ω polyclonal antibody detects endogenous levels of IFN-ω protein.

Bioworld Molecular Weight: ~ 20 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of IFN-ω polyclonal antibody at 1:500 dilution
Lane 1: HEK293T cell lysate
Lane 2: NIH-3T3 cell lysate
Lane 3: H9C2 cell lysate

Immunogen: A synthetic peptide corresponding to residues in Human IFN-ω.

Conjugate: Unconjugated

Modification: Unmodified