yGsy2p-IN-H23 is a potent and first-in-class inhibitor for yeast glycogen synthase 2 (yGsy2p) with an IC50 of 875 µM for human glycogen synthase 1 (hGYS1). yGsy2p-IN-H23 bounds within the uridine diphosphate glucose binding pocket of yGsy2p. yGsy2p-IN-H23 is used for the research of glycogen storage diseases (GSDs).

Product information

CAS Number: 1269190-98-8

Molecular Weight: 377.48

Formula: C23H27N3O2

Chemical Name: 2-methoxy-4-{1-[2-(1-methylpyrrolidin-2-yl)ethyl]-4-phenyl-1H-imidazol-5-yl}phenol

Smiles: CN1CCCC1CCN1C=NC(=C1C1=CC(OC)=C(O)C=C1)C1C=CC=CC=1

InChiKey: YGPHAIXUDLLWHC-UHFFFAOYSA-N

InChi: InChI=1S/C23H27N3O2/c1-25-13-6-9-19(25)12-14-26-16-24-22(17-7-4-3-5-8-17)23(26)18-10-11-20(27)21(15-18)28-2/h3-5,7-8,10-11,15-16,19,27H,6,9,12-14H2,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (264.91 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

yGsy2p-IN-H23 (compound H23) has IC50 values against either hGYS1Δ634S8,11N or wild-type hGYS1 were 161 μM and 875 µM, respectively. yGsy2p-IN-H23 exhibits IC50 values of 280 µM and 263 µM in the absence and presence of G6P for yGsy2p against yeast and human glycogen synthase (GS), respectively. yGsy2p-IN-H23 is not in direct competition with G6P.

Products are for research use only. Not for human use.