NVL Polyclonal Antibody

Catalogue Numbers: BS5832-50, BS5832-100

Sizes: 50µl, 100µl

Alternative Name: Nuclear valosin-containing protein-like; NVLp; Nuclear VCP-like protein

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: O15381

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: Valosin containing protein (VCP), also designated TERA (for transitional endoplasmic reticulum ATPase), is a member of the AAA family of ATPases, which are involved in a variety of cellular activities. VCP is involved in a variety of membrane functions and in the regulation of the cell cycle. VCP associates with ubiquitinated IkB-a as well as with the 26S proteosome, indicating a potential role for VCP in the proteosome-mediated degradation of IkB-a. NVL (nuclear valosin-containing protein-like), also known as NVLp, is an 856 amino acid nuclear protein belonging to the AAA ATPase family. Implicated in ATP-dependent nuclear processes and ribosome synthesis, NVL exists as three alternatively spliced isoforms designated NVL isoform 1 (NVLp.2), NVL isoform 2 (NVLp.1) and NVL isoform 3. Widely expressed, NVL is found at highest levels in pancreas, retina, heart, skeletal muscle and placenta.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: NVL polyclonal antibody detects endogenous levels of NVL protein.

Bioworld Molecular Weight: ~ 95 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of NVL polyclonal antibody at 1:500 dilution
Lane 1: A549 cell lysate
Lane 2: Raw264.7 cell lysate
Lane 3: H9C2 cell lysate

Immunogen: Synthetic peptide, corresponding to amino acids 393-438 of Human NVL.

Conjugate: Unconjugated

Modification: Unmodified