PDE1-IN-3, compound 4 (WO2019156861), is a selective human phosphodiesterase 1 (PDE1) inhibitor. PDE1-IN-3 inhibits PDE4D and PDE6AB with IC50 values of 23.99 μM and 10 μM, respectively.

Product information

CAS Number: 2370966-46-2

Molecular Weight: 312.41

Formula: C18H24N4O

Chemical Name: 3-{[1,1'-bi(cyclopropane)]-1-yl}-7-(cyclobutylmethyl)-5,6-dimethyl-7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-8-one

Smiles: CC1=C(C)N(CC2CCC2)C(=O)C2=NN=C(N12)C1(CC1)C1CC1

InChiKey: ZLTYIDKHKFGNFO-UHFFFAOYSA-N

InChi: InChI=1S/C18H24N4O/c1-11-12(2)22-15(16(23)21(11)10-13-4-3-5-13)19-20-17(22)18(8-9-18)14-6-7-14/h13-14H,3-10H2,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

IC50: 23.99 μM (PDE4D); 10 μM (PDE6AB)

Products are for research use only. Not for human use.