PC Alkyne-PEG4-NHS ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Product information

CAS Number: 1802907-98-7

Molecular Weight: 653.63

Formula: C29H39N3O14

Chemical Name: 2,5-dioxopyrrolidin-1-yl 1-(5-methoxy-2-nitro-4-{3-[(3,6,9,12-tetraoxapentadec-14-yn-1-yl)carbamoyl]propoxy}phenyl)ethyl carbonate

Smiles: COC1=CC(C(C)OC(=O)ON2C(=O)CCC2=O)=C(C=C1OCCCC(=O)NCCOCCOCCOCCOCC#C)[N+]([O-])=O

InChiKey: AOWMPLACVFKCJJ-UHFFFAOYSA-N

InChi: InChI=1S/C29H39N3O14/c1-4-10-40-13-15-42-17-18-43-16-14-41-12-9-30-26(33)6-5-11-44-25-20-23(32(37)38)22(19-24(25)39-3)21(2)45-29(36)46-31-27(34)7-8-28(31)35/h1,19-21H,5-18H2,2-3H3,(H,30,33)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Products are for research use only. Not for human use.