Pyrene-PEG5-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 1817735-33-3

Molecular Weight: 503.59

Formula: C30H33NO6

Chemical Name: N-(3,6,9,12,15-pentaoxaoctadec-17-yn-1-yl)pyrene-1-carboxamide

Smiles: C#CCOCCOCCOCCOCCOCCNC(=O)C1=CC=C2C=CC3C=CC=C4C=CC1=C2C=34

InChiKey: XGANKSIJSRXKLW-UHFFFAOYSA-N

InChi: InChI=1S/C30H33NO6/c1-2-13-33-15-17-35-19-21-37-22-20-36-18-16-34-14-12-31-30(32)27-11-9-25-7-6-23-4-3-5-24-8-10-26(27)29(25)28(23)24/h1,3-11H,12-22H2,(H,31,32)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Products are for research use only. Not for human use.