TRPV1 Polyclonal Antibody

Catalogue Numbers: BS60454-50, BS60454-100

Sizes: 50µl, 100µl

Alternative Name: Transient receptor potential cation channel subfamily V member 1; TrpV1; Capsaicin receptor; Osm-9-like TRP channel 1; OTRPC1; Vanilloid receptor 1; TRPV1; VR1

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q8NER1

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: Vanilloid receptor 1 (VR1), also designated capsaicin receptor, is a nonselective cation channel, structurally related to members of the TRP family of ion channels. VR1 is activated by capsaicin, the active ingredient in chili peppers, by heat and by an increase in protons at sites of infection, inflammation and ischemia. By creating moderately acidic conditions, protons are able to lower the temperature threshold for VR1 activation, thus identifying VR1 as a molecular integrator of chemical and physical stimuli that elicit pain. VR1 is expressed in primary sensory neurons and vagal nerves and activated VR1 induces the influx of cations, particularly Ca2+ and Na+ ions. The vanilloid receptor may also be a molecular target for endogenous anandamide, in addition to the cannabinoid receptors, in the nervous and cardiovascular systems.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: TRPV1 polyclonal antibody detects endogenous levels of TRPV1 protein.

Bioworld Molecular Weight: ~ 94 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of TRPV1 polyclonal antibody at 1:500 dilution
Lane 1: Hela whole cell lysate
Lane 2: Raw264.7 whole cell lysate
Lane 3: PC12 whole cell lysate

Immunogen: A synthetic peptide corresponding to residues in Human TRPV1.

Conjugate: Unconjugated

Modification: Unmodified