PC SPDP-NHS carbonate ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Product information

CAS Number: 2279944-61-3

Molecular Weight: 608.64

Formula: C25H28N4O10S2

Chemical Name: 2,5-dioxopyrrolidin-1-yl 1-[5-methoxy-2-nitro-4-(3-{[2-(pyridin-2-yldisulfanyl)ethyl]carbamoyl}propoxy)phenyl]ethyl carbonate

Smiles: COC1=CC(C(C)OC(=O)ON2C(=O)CCC2=O)=C(C=C1OCCCC(=O)NCCSSC1=CC=CC=N1)[N+]([O-])=O

InChiKey: ZFTXYOZPURXCEF-UHFFFAOYSA-N

InChi: InChI=1S/C25H28N4O10S2/c1-16(38-25(33)39-28-23(31)8-9-24(28)32)17-14-19(36-2)20(15-18(17)29(34)35)37-12-5-6-21(30)26-11-13-40-41-22-7-3-4-10-27-22/h3-4,7,10,14-16H,5-6,8-9,11-13H2,1-2H3,(H,26,30)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Products are for research use only. Not for human use.