DI-82 is a potent deoxycytidine kinase (dCK) inhibitor with an IC50app of 27.8 nM and Kiapp of 9.2 nM. DI-82 has antitumor activity.

Product information

CAS Number: 1638148-50-1

Molecular Weight: 510.65

Formula: C20H26N6O4S3

Chemical Name: N-[2-(5-{4-[(1R)-1-[(4,6-diaminopyrimidin-2-yl)sulfanyl]ethyl]-5-methyl-1,3-thiazol-2-yl}-2-methoxyphenoxy)ethyl]methanesulfonamide

Smiles: CC1SC(=NC=1[C@@H](C)SC1N=C(N)C=C(N)N=1)C1=CC(OCCNS(C)(=O)=O)=C(C=C1)OC

InChiKey: MBPWFMBRNJJXFY-GFCCVEGCSA-N

InChi: InChI=1S/C20H26N6O4S3/c1-11-18(12(2)32-20-24-16(21)10-17(22)25-20)26-19(31-11)13-5-6-14(29-3)15(9-13)30-8-7-23-33(4,27)28/h5-6,9-10,12,23H,7-8H2,1-4H3,(H4,21,22,24,25)/t12-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

DI-82 (compound 12R) has an IC50 of 3.7 nM in CCRF-CEM acute lymphoblastic leukemia cells. DI-82 (1 μM) has a NADPH-dependent CLint of 22.7 μL/min•mg and a NADPH-dependent T1/2 of 102 mins in a standard microsomal liver clearance assay. DI-82 (200 μM) completely blunts the ability of decitabine to bind human thymidylate synthase (TS).

Products are for research use only. Not for human use.