ALPP Monoclonal Antibody

Catalogue Numbers: MB66674-50, MB66674-100

Sizes: 50µl, 100µl

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Swiss-Prot: P05187

Host: Mouse

Reactivity: Human

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: Mammalian alkaline phosphatases (APs) are highly conserved zinc-containing allosteric enzymes that are able to hydrolyze and transphosphorylate a wide range of compounds. There are four known human alkaline phosphatase isozymes: TNAP (tissue-nonspecific; bone/liver/kidney), ALPP (placental), ALPP2 (germ cell), and ALPI (intestinal). Placental alkaline phosphatase (ALPP) is bound to the plasma membrane via a glycosyl-phosphatidylinositol (GPI) anchor. It is expressed primarily in the placenta and may be involved in transplacental IgG transport. ALPP has been found to be overexpressed on the surface of several different types of solid tumor cells and elevated serum concentrations of ALPP and ALPP-like enzymes has been found to be associated with ovarian, cervical, and testicular cancer.

Purification and Purity: The antibody was purified by immunogen affinity chromatography.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of ALPP protein.

Extra Notes: Western blot analysis of ALPP expression in HepG2 (A), Hela (B) whole cell lysates.

Bioworld Molecular Weight: ~ 70 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: PLAP; Alkaline phosphatase placental type; Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1; PLAP-1

Immunogen: Purified recombinant Placental alkaline phosphatase (PLAP) protein fragments expressed in E.coli.

Conjugate: Unconjugated

Modification: Unmodified